https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31258 Wed 11 Apr 2018 14:27:05 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18290 Wed 11 Apr 2018 14:18:28 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30590 Wed 11 Apr 2018 10:46:14 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20672 Tue 15 Sep 2015 09:41:54 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49281 Enterovirus genus in the family Picornaviridae. Different RVs bind to one of three known cellular receptors (intercellular adhesion molecule-1, low density lipoprotein receptor, and cadherin-related family member 3) on airway epithelial cells to initiate their replication cycle. Strategies to categorize RVs have been shaped by increased understanding of virus biology and have passed through several iterations since virus discovery in the 1950s. The RVs are currently classified into over 160 types within three species (A, B, and C) based on phylogenetic sequence criteria and distinct genomic features. An understanding of RV structure, replication, and diversity is necessary to develop novel treatment strategies. This chapter will provide an overview of the structural and genetic features that distinguish RV species, as well as methods of RV classification.]]> Tue 14 Nov 2023 14:44:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17092 Sat 24 Mar 2018 08:05:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19672 Sat 24 Mar 2018 08:01:12 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21650 Cryptosporidium is an enteric parasite of public health significance that causes diarrhoeal illness through faecal oral contamination and via water. Zoonotic transmission is difficult to determine as most species of Cryptosporidium are morphologically identical and can only be differentiated by molecular means. Transmission dynamics of Cryptosporidium in rural populations were investigated through the collection of 196 faecal samples from diarrheic (scouring) calves on 20 farms and 63 faecal samples from humans on 14 of these farms. The overall prevalence of Cryptosporidium in cattle and humans by PCR and sequence analysis of the 18S rRNA was 73.5% (144/196) and 23.8% (15/63), respectively. Three species were identified in cattle; Cryptosporidium parvum, Cryptosporidium bovis and Cryptosporidium ryanae, and from humans, C. parvum and C. bovis. This is only the second report of C. bovis in humans. Subtype analysis at the gp60 locus identified C. parvum subtype IIaA18G3R1 as the most common subtype in calves. Of the seven human C. parvum isolates successfully subtyped, five were IIaA18G3R1, one was IIdA18G2 and one isolate had a mix of IIaA18G3R1 and IIdA19G2. These findings suggest that zoonotic transmission may have occurred but more studies involving extensive sampling of both calves and farm workers are needed for a better understanding of the sources of Cryptosporidium infections in humans from rural areas of Australia.]]> Sat 24 Mar 2018 07:52:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4867 Sat 24 Mar 2018 07:18:44 AEDT ]]>